I have written lots of articles about the rotation issue with Crystal Reports and Zebra printers. Apparently it can still crop up since I just helped a customer with this issue.  They installed the drivers from Seagull Scientific which usually solves the problem.  But in this case, once they had the drivers installed, the problem didn’t go away.  But after they re-calibrated the printer to the label media, the issue went away for them.  I am sharing the steps just in case this comes up for anyone else. These are the steps for the Zebra GK420d desktop printer:

1) Holding the feed button down
2) Wait until it blinks once, then blinks twice in quick succession.
3) Immediately release the button
4) It will automatically print out a few labels or so to figure out the dimensions.

(and thanks to Samuel Lindemulder of Kentwood Powder Coat for sharing these steps.)